Scientists: Bustle increases risk of Alzheimer's disease

Purdue University scientists have created a device that mimics the human brain and identified a mechanism that links head injuries to an increased risk of Alzheimer's disease.

  As Vesti.az reports with reference to Lenta.ru, this was reported in an article published in Lab on a Chip magazine.

  The device, called "traumatic brain injury on a chip," allows us to monitor the effects of concussive forces on brain organoids containing neurons in mouse embryos.  Three-dimensional cultures of nerve tissue were subjected to impacts of 200 G, roughly equivalent to what a soccer player receives in a single kick.

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  The exposure resulted in a rapid increase in the production of acrolein — an acrylic acid aldehyde associated with oxidative stress and neurodegenerative diseases — and an increase in misfolded clumps of the amyloid beta 42 protein, which forms in amyloid plaques in people with Alzheimer's disease.  is found.  In addition, it was found that the longer acrolein acted on the cells, the more amyloid plaques it caused to accumulate.

  Within the first 24 hours after exposure, acrolein levels increased in neuronal clusters and production of misfolded Ab42 increased by 350%.  Acrolein disrupts normal AB42 by binding to regions of the protein that are important for structural stability.  However, a physical effect on a correctly folded protein is also sufficient to cause misfolding of AB42.

  Going forward, the scientists plan to add several additional features that will allow them to measure the minute forces experienced by the cells during impact and to perform biochemical tests such as acrolein levels without removing the cells from the test chamber.  will allow